Zelnate® DNA Immunostimulant

Zelnate® DNA Immunostimulant is the first licensed immunostimulant that aids in the treatment of BRD due to Mannheimia haemolytica in cattle 4 months of age or older, when administered at the time of, or within 24 hours after, a perceived stressful event. Zelnate jumpstarts the animal’s own defense system to help fight this infectious disease.

Species / Premise

  • beef
  • dairy


  • Bovine Respiratory Disease

Product Type

  • Immunostimulant

Product Category

  • Zelnate has demonstrated in research studies to significantly reduce lung lesions and mortality (death loss) compared to untreated animals (P < 0.05)
  • IM (intramuscular) administration - No injection site lesions were observed during field safety studies
  • Unique DNA liposome complex stimulates the innate immune system in cattle - The innate immune system has been shown to provide a rapid, potent and broad protective response to infectious agents
  • A novel technology that enhances an animal’s natural defenses and contains no antibiotics and no preservatives
  • Available in 5, 10 and 50 dose package sizes

It’s not an antibiotic. It’s not a vaccine. It’s Zelnate®.

For more information about Zelnate, visit

For more information about immunology and innate immunity, please visit

Zelnate® DNA Immunostimulant FAQs

What is Zelnate®?

What is a DNA immunostimulant, and how does it work?

How is Zelnate® different from other immunostimulants on the market?

Why is there a need for something like Zelnate®?

What is Zelnate® indicated for?

What is BRD? How common is it?

Is Zelnate® an antibiotic or vaccine?

For what age of cattle is Zelnate® indicated?

How is Zelnate® administered?

When should Zelnate® be used?

What needle do you recommend using with Zelnate®?

Why is there a multi-step mixing approach for Zelnate®?

How should Zelnate® be mixed?

Will Zelnate® work if I mix it incorrectly?

How long can I store Zelnate® after opening?

How many doses are in a bottle of Zelnate®?

Why do we need immunostimulants in the livestock industry?

Zelnate® Mixing and Administration Video


See how easy it is to mix and administer Zelnate in this instructional video.

Zelnate® and It's not an antibiotic. It's not a vaccine. It's Zelnate., and Zeedle are trademarks of Bayer.

Zelnate is based on technology developed by Juvaris BioTherapeutics and is patent protected. Animal Health applications are being exclusively developed by Bayer Animal Health and are the subject of Bayer patent applications.