Baytril® 100 (enrofloxacin) Injectable for Cattle

Baytril® 100 for Cattle is a sterile, ready-to-use injectable antimicrobial solution for treating bovine respiratory disease (BRD), that contains enrofloxacin, a broad-spectrum fluoroquinolone antimicrobial agent.

Species / Premise

  • beef
  • dairy
  • Non-Lactating Dairy Cattle


  • Bovine Respiratory Disease

Product Type

  • Injectable

First. Baytril 100 for Cattle is the first single-dose fluoroquinolone FDA-approved for the treatment of bovine respiratory disease (BRD) and the control of BRD in beef and non-lactating dairy cattle at high risk of developing BRD.

Four major BRD pathogens. Baytril 100 has bactericidal activity against the major bovine pathogens Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis.

Bactericidal. Baytril 100 has a mode of action that actually kills the bacteria causing infection by destroying bacterial DNA and preventing bacterial replication.

Concentration-dependent. Baytril 100 is concentration-dependent, delivering effective therapeutic drug concentrations with a single dose.

Effective. In cattle, Baytril 100 reaches therapeutic drug concentrations at the site of infection in the lung in 1-2 hours.1

Kills the bacteria. In vitro,* Baytril 100 kills 97% of BRD-causing bacteria in 1-2 hours.*2 And the sooner bacteria are killed, the faster a calf will feel better and get back to work eating.

Easy syringability. Baytril 100 is syringable in cold weather3, making it an easily stored injectable solution (do not refrigerate; and protect from freezing and exposure to direct sunlight).

Beef & Dairy. Baytril 100 is approved for use in non-lactating dairy cattle, including dairy replacement heifers < 20 months of age.

Subcutaneous. Single-dose Baytril 100 is administered by a subcutaneous injection in compliance with BQA guidelines.

Available in three convenient sizes. Baytril 100 lets you select the bottle size that best fits your needs. Look for it in the 100 mL, 250 mL and 500 mL amber glass bottles.

*The clinical significance of in vitro data has not been determined.

Baytril® 100 (enrofloxacin) Injectable for Cattle FAQs

What is the Cattle Single-Dose Therapy for Baytril® 100 (enrofloxacin) Injectable for Cattle?

What is the Cattle Multiple-Day Therapy for Baytril® 100 (enrofloxacin) Injectable for Cattle?

What puts calves at risk of developing BRD?

What are the product sizes for Baytril® 100 (enrofloxacin) Injectable for Cattle?

How should Baytril® 100 (enrofloxacin) Injectable for Cattle be stored and disposed?

Does Baytril® 100 (enrofloxacin) Injectable for Cattle allow for flexible dosages?

What is the Baytril® 100 (enrofloxacin) Injectable for Cattle dose and treatment schedule for cattle?

What are the risks and warnings for Baytril® 100 (enrofloxacin) Injectable for Cattle?

1Davis JL, Foster DM, Papich MG. (2007). Pharmacokinetics and tissue distribution of enrofloxacin and its active metabolite ciprofloxacin in calves. J Vet Pharmacol Ther. 30(6):564-571.

2Blondeau JM, Borsos S, Blondeau LD, Blondeau BJ, Hesje C. (2005). The killing of clinical isolates of Mannheimia haemolytica (MH) by enrofloxacin (ENR) using minimum inhibitory and mutant prevention drug concentrations and over a range of bacterial inocula. In: ASM Conference on Pasteurellaceae; 23-26 October 2005; Kohala Coast, Big Island, Hawaii: American Society of Microbiology; Abstract B12.

3Syringeability and viscosity testing of Baytril 100 Injectable Solution – Report 03-02 (BL3168).

*The clinical significance of in vitro data has not been determined.

Federal law restricts Baytril 100 to use by or on the order of a licensed veterinarian. Extra-label use of Baytril 100 in food-producing animals is prohibited. Cattle intended for human consumption must not be slaughtered within 28 days from the last treatment. This product is not approved for female dairy cattle 20 months of age or older, including dry dairy cows. Use in these cattle may cause drug residues in milk and/or in calves born to these cows. The effects of enrofloxacin on cattle or swine reproductive performance, pregnancy and lactation have not been determined. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

Baytril is a registered trademark of Bayer.